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Residence Inn by Marriott Durham McPherson/Duke University Medical Center Area

4.5

1108 W Main St
Durham, NC 27701
Phone: (919) 680-4440
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Host your private meeting, small forum, weddings, and special occasion. The property offers a prime location near Duke University, North Carolina Central University and Durham Performing Arts Center, and the hotel makes it easy for meeting attendees to discover some of the area's top attractions.


Google Reviews

Photo of Lori Childers Lori Childers
Feb 26, 2026 3

As a Marriott Bonvoy Titanium Lifetime member, I stay in Marriott properties frequently, so I have a solid frame of reference. The positives: the location in Durham is convenient, the room was spacious with modern décor, and the bathroom was exceptionally large with a generous vanity area — definitely a highlight. Unfortunately, the stay itself was not restful. The HVAC unit was extremely loud and cycled on and off throughout the night. There was no apparent way to turn it off for sleeping, and it repeatedly woke us up. The refrigerator was older and made a constant ticking/compressor noise, which only added to the disruption. Parking is also very limited — minimal surface spaces, a very small garage, and paid parking on top of that. We reported the HVAC noise and missing body wash to Tiffany and a woman who appeared to be a manager (Scott). While they were polite, no points or compensation were offered. Given the noise issues and parking limitations, we would choose other nearby hotels in Durham if future visits are required.

Photo of Daniel Petit-Frere Daniel Petit-Frere
Feb 19, 2026 5

My job had us stay here from January 30th to February 2nd, 2026 due to a snowstorm. By far, I felt a luxurious experience having a fully furnished sweet. I had a beautiful view of downtown Durham (Trinity Park), attractions are walking distance and complimentary breakfast 🍳. Would definitely recommend Residence Inn

Photo of Sabrina Reams Sabrina Reams
Jan 18, 2026 5

This Hotel was very nice the service was Great we rented the Conference room for a 50th birthday celebration. The Employees was very friendly Front Desk Rep. Tiffanett (sp) was very polite friendly ready to assist and Richard the maintenance guy was amazing also. I Recommend anyone thats looking for an event space to stop by.

Photo of p c p c
Jan 5, 2026 5

This place came through for me big time, and I will always be grateful for that. I had originally booked a room at the Sonesta ES, for a one month stay with two cats. On 1/3, around 3 hours before I was due to check in, I called to confirm my arrival and was told that they no longer accept cats. After a talk with the manager, I was told that I could bring ONE cat only, which is a bit like saying I could only bring along one child. I called several other hotels and found that "pet friendly" means they accept dogs, not cats. When I called this Residence Inn, they were able to find me a same day reservation, AND had no problem accepting both of the kitties. Thank you so much, Residence Inn! Also, so far the room is comfortable, it's small but laid out very cleverly, and I'm pretty happy overall.

Photo of Lyfesjewel Lyfesjewel
Dec 19, 2025 4

Great hotel in a fantastic location. Close to Duke University Medical Center. Nice spacious room. Bathroom needed more attention on cleaning and some recaulk around shower. Kitchen sink needs a good scrubbing to clean around the edges. Family was in room for 10m and started having sneezing fits. Other than that everything was good. Put ice makers on the floors for guest please.

Photo of Clint Rodenfels Clint Rodenfels
Nov 30, 2025 4

Best two things about this hotel are the staff and the location. Starting with Tiffani at the front desk and then everyone else we encountered in the 9 days we stayed, staff is exceedingly friendly and welcoming. The hotel is perfectly located close to food, bars, campus, and shopping without the hassle of downtown parking. With a small open lot in back of the building, a covered garage, and a large open lot, there was always space available, no matter when we arrived and it was easy to navigate. This is an older RI property and it shows in some areas. While some upgrades have been made with a well outfitted gym and brand new LG machines in the guest laundry, some of the room furniture was well used and past the point of needing to be replaced. That said, the hotel is clean, convenient, and close to so much downtown. No regrets staying here and would do it again.

Photo of Rojen Jacob Rojen Jacob
Nov 18, 2025 4

Very clean rooms and friendly staff. Breakfast is sub par, but you get what you pay for. Parking is limited in front of the hotel and in the attached garage. There is more parking across the street. Parking in $15 a day.

Photo of Ann Staples Ann Staples
Nov 9, 2025 5

I had an excellent experience. The property is beautiful and clean. The staff is extremely kind and helpful. I love that they have a Book Nook incase you need a good read!

Photo of W M-K W M-K
Aug 28, 2025 5

This past weekend, we hosted a surprise birthday celebration at this location, and it could not have gone better! Since we flew in from out of state, we needed both a place to stay and a venue, and I am so glad my event planner recommended the Residence Inn by Marriott in Durham, NC. From the very beginning, Megan, the Sales Manager, was incredible. She communicated seamlessly with both me and my planner, making sure every detail was handled. Megan went above and beyond—she created a signature cocktail just for the event, kept track of my bar tab, provided everything we needed for the space, and even stayed late into the evening to ensure everything ran perfectly. I truly cannot put into words how grateful I am for her dedication and professionalism. Her team was just as wonderful. Danasha made sure check-in went smoothly and was such a pleasure to work with. She, along with her predecessor (whose name unfortunately escapes me), also helped keep a second surprise under wraps, my sister flying into town for the event! Their teamwork and care made the entire experience even more special. I am beyond impressed with the level of service, warmth, and effort from everyone involved. This team went over and beyond, and because of them, the night was absolutely unforgettable.

Photo of Beyer Brandon Edward Beyer Brandon Edward
May 5, 2025 5

Not a bad experience, but the room didn’t meet my expectations. It was a bit smaller than advertised and the Wi-Fi connection was weak. The staff was helpful, though, and the breakfast was good.

Photo of M. Melody Morrison-McCallie (Melody M. McCallie) M. Melody Morrison-McCallie (Melody M. McCallie)
Apr 11, 2025 5

Excellent stay! Service was above & beyond anything I've experienced including luxury destinations! Thank you Megan for room booking & details. I won't even consider looking anywhere else in the Durham area. This is IT for me!

Photo of Krishna Narasimhan Krishna Narasimhan
Mar 31, 2025 4

Stayed here for a couple of nights. Used to Mobile app and requested a notification when the room was ready and got a mobile key, unfortunately didn’t receive a notification. Perhaps the system is flawed. Once we arrived we parked the car in the covered lot on the property. So it felt secure. The lobby itself was large and roomy. The room was nice and clean and fairly large. The breakfast was not extensive but definitely had enough variety. The staff were friendly and helpful. Overall, a good stay and we would come back.