The Hampton Inn & Suites Durham University Medical Center is at the intersection of Interstate 85 and Cole Mill Road, just two miles from Duke University and Duke Medical Center. North Carolina Central University is six miles from the front door and downtown Durham attractions such as Durham Performing Arts Center (DPAC), Durham Bulls Athletic Park, restaurants, and bars are only four miles away. Breakfast and Wi-Fi is included in the guests stay as well as access to the fitness center and indoor heated pool.
This is the best Hampton Inn we've ever stayed at, definitely 5 stars. It looks new, very clean, with an amazing first floor level. Front desk was very friendly, always staffed, bottled water was in our room. The hallway and room was spotless and comfortable. Breakfast area is huge, lots of seating, large selection, multiple waffle irons, much more than other Hampton Inns. Definitely recommend!
Opici Becton
Sep 19, 2025
5
My family was in town for our Aunts Funeral and most family members who come from up North like downtown durham accommodations. But we were able to get them to stay here and they are so happy with the hotel, the breakfast and location to the family house is around the corner. The expectation of home away from home was super 👌. Thank you so much. Plenty seating and the view of the back where you had plenty sun space. I may do a Friday home away from home stay myself. Whewwww! And Ms. Terry was absolutely amazing...greeting guest and welcoming those coming in to check in. Keep up the amazing job and lets not forget those who keep the hotel clean and put the breakfast spread out ...Thank you allllll! This will be our family hotel.
John Brown
Sep 18, 2025
5
The first impressions start at the check-in desk. The associates were extremely welcoming, professional & courteous. Mr. T & Ms. Mimi were highly efficient, great sense of humor and thorough. I highly recommend this location, due to the impeccable rooms, location and cleanliness. It is above reproach. Great Job.
Sona Bhatnagar
Sep 16, 2025
5
Hampton Inn and Suites by Hilton - Durham University Medical Center, NC
This was the best Hampton Inn and Suites that we have stayed at for many reasons. First of all, the hotel itself was very clean, bright, and airy. Our bedroom was huge with big windows, the beds were sooo…..comfortable, big bathroom, plenty of fresh clean towels, the water pressure was perfect and the hot water was magnificent. Parking is free and secure.
The staff was all exceptional so I cannot name a particular person. They were all friendly and helpful.
The evening cookies were freshly made and warm (thank you for that); there is fresh coffee and tea all day long/24 hours and constantly refreshed. The breakfast was the best we have ever seen in such hotels with lots of variety of breads, muffins, cakes, 4 waffle irons, eggs, meats, cheese, yogurt, oatmeal with all the fixings and real fruit.
The swimming pool was pretty large, clean, the gym area had a lot of high-end equipment inducing weights, kettlebells, treadmills, 4 peloton bikes and more! There were even 4 washer and dryers for use.
I would just come here to stay for no reason.
Allison Johnson
Sep 10, 2025
5
We had a very comfortable stay here! They have the best free hotel breakfast! They had blueberry waffles and different toppings as well as oatmeal AND grits. Lots of fruit and muffins, lemon water. I was really impressed with the variety. We stayed for one night while I was being seen at Duke. It’s only 10-15 mins from Duke’s hospitals in Durham and the University so it’s a very convenient location for patients and visitors. They also have medical rate which saves you money! Our room was spacious, clean and modern. The temperature and water pressure were fantastic in the shower! Bed was comfortable and the hotel staff were all helpful and friendly. The room was quiet and location felt safe. We didn’t get to use any of the amenities but the fitness area looked nice and clean as well. Even the elevators were clean! They do contactless entry with the Hilton app which makes check in and check out easy. This will be our go-to hotel when we’re in Durham!
Elise D
Aug 12, 2025
5
Great stay here! The rooms were clean and comfortable - I liked the fitness center and FINALLY! A fitness center that isn't 80 degrees! It was cool and comfortable in there for my run in the morning. I liked the selection of equipment and everything was nice and clean. The only item I might suggest is to bring soap. We were surprised to find that they don't provide soap (?) and only provide a body wash. Overall though, a very nice stay!
mygglreviews Acct
Jul 31, 2025
3
Rooms were ok but blah and on the small side. Clean, plenty of towels. A bed or 2, a desk chair, and a decent bathroom. Nothing within walking distance but a few low-end chains, and highway noise is pretty loud even on the top floor. Not worth the site's $140 price tag unless you really need to be close(ish) to Duke/I-80 and the similarly-priced Duke Hilton is out of rooms. Rescued by the absolutely terrific buffet breakfast and pet-friendly status.
Sydney Tomlin
Jun 7, 2025
5
This hotel is one of the best Hampton Inns and overall hotels that I've stayed at in a while. First of all, the staff works so hard and are very friendly and approachable, which is not a given nowadays. Briana, Priscilla, and Terry each helped me and my family to feel welcome and at home. They are truly top notch.
The cleanliness is 5 out of 5, which is saying something with my particular high standards. The staff stays on top of everything in this relatively new hotel. Even when really busy, the hotel feels quiet and privacy is respected. The rooms are clean and the TV's are really nice.
Highly recommend this hotel. Convenient location to Duke University, Duke hospitals, and quick eateries. It can be tough to merge onto the busy main road, but otherwise, it's great.
Joe R
Apr 17, 2025
5
As a Bonvoy Platinum member, I rarely venture outside the Marriott world -- but I'd make a whole lot of exceptions for this hotel. Amazing service, comfortable rooms where things "just work" -- even a wonderful breakfast. The attention to detail in the rooms was what impressed the most. Little things that don't work at most hotels didn't cause any hassle here. Other hotels could learn a lot.
marian tabak smith
Apr 12, 2025
5
I agree with other reviews. This place is great. Best buffet breakfast I have ever eaten. Staff is great. Rooms are spotless. Rooms have plenty of electric outlets. Great shower. Refillable water bottle station, and cookies in the evening. I appreciate the message I received after I booked, information that may not be on my third party site. It may be helpful to others. Lots of fast food within walking distance. Only negative is: it's hard to get out of the complex due to really busy hwys.
Vanessa Infanzon
Apr 11, 2025
5
I stayed here for business and it was the hotel I needed after several weeks of travel in a variety of hotels, inns and airbnbs. My room was a king on the Hampton Inn side - clean, plenty of light, room to move around, a sofa and a desk to work. The bed and pillows were comfortable. The hotel is quiet and has great shades to block the light for sleeping. The hotel is minutes away from Durham attractions.
Dorrell at the front desk was helpful when I had a few questions. I would definitely stay here again.
Jeanne T
Apr 9, 2025
5
All I can say is that I was extremely impressed with this hotel. Briana truly made my day by allowing me to check in early. I was in town visiting some friends in the hospital, and her graciousness was greatly appreciated.
I have stayed in thousands of hotels in this category, and I must say—this was the best experience I’ve ever had.
My only minor issue was the inability to fully turn off the air-conditioning unit. I was told that the fan continues to run, even after selecting "off," due to a built-in dehumidifier function. As a Floridian, I understand the need, but the constant buzzing wasn’t my favorite part of the stay.
christine tai
Mar 23, 2025
5
Truly enjoyed our stay here. Love the spacious room, clean and quiet, with hot breakfast (vegetarian friendly). Gym was great for work out. Staff at front desk were friendly and helpful. Would love to stay again if we visit Durham next time.
Ashley Thompson
Feb 18, 2025
5
Clean large rooms with comfortable desk space, perfect for me to catch up on work emails and reports. Plenty of lighting and charging stations throughout the room. Breakfast included. Has a filtered water station in lobby. Free cookies and chocolate mint candies. Close to restaurants and conveniences. I Enjoyed my short business stay!
Wendy
Jan 18, 2025
5
We stay here each time we have appointments at Duke. The hotel is lovely and all of the employees are very friendly and helpful. Priscilla is wonderful! She always has a smile for us and we look forward to seeing her when we check in. We would highly recommend this beautiful hotel.
Claus
Jan 16, 2025
5
FROM CHECK-IN through breakfast every measure of hospitality was a benchmark of service. The breakfast offering in a hotel setting would meet the most discriminating guest. The staff is an example of superior trading. Of note is Mary Torres. A simple question was met with service and a smile. A team member to exceed all corporate s tandards.
benjamin luna
Jan 10, 2025
4
The hotel was very nice, clean and most importantly, quite. The elevators were fast and very clean. The rooms themselves are updated, clean, and inviting. The beds are pretty comfortable, but everyone likes different firmness, so this comment about the beds is very subjective. The bathrooms were very clean and bright, stocked with enough towels, and hot water worked well. The morning breakfast is on par with a hotel provided breakfast, so if you are wanting a "knock your socks off" type breakfast, you will be disappointed. The hotel provided breakfast is not bad... but not exciting either. There are multiple choices to fit many diets which is a huge plus. My one and only complaint is the location of entrances & exits to and from the main road. Very, very difficult to make a left turn as only right turns are supported. Summary: the price was good, room was great, breakfast is good, and everything was clean! Recommend staying in this hotel if you are in the area.
Karen Trauner
Nov 30, 2024
5
I've stayed in every mid-level hotel around here, as I've been visiting friends in the area twice a year for the last 18 years or so. I've never found one I would happily rebook...until now.
This Hampton Inn is pretty much perfect.
First, the lobby is beautiful. Plenty of elevators. Coffee/tea bar at all hours. There was a Hot Cocoa bar with all kinds of topping options when we were there as well. And the breakfast! The best I've seen. Waffles, cereal, omelets, sausage, oatmeal, fresh(!) fruit, more. The selection of toppings (about six different things for oatmeal, and lots for waffles) was amazing. Lots of seating, including at bar height, regular tables and couches. There were several over-the-couch side tables available too, if you wanted to pull one up for your plate. And the couches had built in charging ports on the ends.
The room itself was lovely. Outlets, including for USB, everywhere. The shower was fantastic, plenty of hot water and lots of force. There was a comfortable chair in the corner, an extra blanket in the closet, microwave, fridge, and coffee in the room. We had downloaded a digitial key from the app, so just used our phones for entry, and never had to check in (or out) at the front desk.
The bed was very firm but comfortable. The pillows were perhaps a bit too soft for my personal liking, but if it was a big deal to me I would have brought my own pillows. They were fine.
The only addition I'd make to the room would be an extending-arm make-up mirror in the bathroom, because the wall mirror was too far away for me to apply make-up easily. Other than that, I wouldn't change a thing!
The hotel is dog friendly, too, with many clean-up stations conveniently located along the grassy areas.
I know this is a fairly new hotel. I hope it maintains this level of customer service (front desk staff member was very friendly when I asked her a quick question because I was confused that the same building was both a Hampton Inn and a Home2; cafe staff was also very nice and actually cleared our table while we lingered over coffee), cleanliness, and amenities as it ages.
We'll definitely be back!
Kathryn Copeland
Nov 14, 2024
5
The rooms are spacious, clean and comfortable. The breakfast is wonderful! Priscilla at the front desk was such a great help. She is kind, professional and always glad to assist. This is our second stay at this hotel and we will definitely be back!
Francesca Kober Sauls
Nov 14, 2024
5
I had a wonderful experience staying at the Hampton Inn. My husband was staying overnight at Duke after a surgery and I needed a comfortable and safe place to stay the night, so I could head back to the hospital the next morning. I was warmly welcomed by Wayne & Priscilla. Wayne took extra special care to tell me about the amenities such as breakfast as well as letting me know that a staff member is available 24/7 at the concierge desk if I needed anything. It was a wonderful feeling to take the elevator up to my room knowing that I was taken care of. The room was clean, modern, and I enjoyed how easy it was to access Netflix on the TV. I woke up the next morning, ate a hearty breakfast from the buffet and walked over to concierge as I was about to check out. I had a wonderful conversation with another staff member at the concierge desk, and I checked out with ease. Overall A+++, the service from the staff was exceptional.
Jessica Proffitt
Nov 1, 2024
5
Room was very clean and spacious for intended purposes. Staff was warm and welcoming from the first interaction to the last! Wayne was amazing and very knowledgeable. He also gave us a little snack bag after long travels! Breakfast was huge with so many different options to meet many expectations/nutritional needs. The kids loved the pool, it was clean and well maintained as well. We really have no complaints. I mean the snack area was pricey but that’s not the hotels fault as much as it is being the convenience of it. Many games in the outside area along with fire pits, grills and plenty of seating. They had applicable parking and charging stations as well. We stayed under Derek Farley/Heather Wood. Would recommend and will always stay here when we are in the area. Sorry for the lack of room pictures. I didn’t think to take any before using the room!
Alina Mirza
Oct 26, 2024
5
Amazing hotel, it’s nice and clean and the manager and staff are really nice. They have a breakfast in the morning and while doing some work in the lobby the manager came and gave some ice cream, super nice! Location isn’t too horrible, there’s nice places that are a few miles out but nothing super nice close by. This is still a great hotel and would definitely def recommend.
Donald Staples
Oct 21, 2024
5
Excellent Hampton Inn in Durham, NC! Our check in was very efficient. The front desk attendant “Wayne” was exceptional. Wayne was very professional and personable. He explained all the extra amenities in great detail. This Hampton has a lot more to offer than the ones I have stayed in the past. It is also part of the Home 2 Suites, which is definitely unusual. Great job Wayne!
